Chemistry of RNA and DNA for new therapeutic strategies

The aim of this course is to provide an understanding of the chemical strategies to modify nucleic acids (DNA and RNA). This will include chemistry of amino acids, nucleosides and nucleotides. 

At the end of this course, students will be able to play with protecting groups and orthogonal reactions and to use synthetic and enzymatic methodologies for post-functionalization and bioconjugaison of biomolecules. 

Some applications will be also discussed, such as the use of modified biomolecules and conjugates and bisubstrate concept in the field of new therapeutical strategies, for targeted, delivery and to produce DNA-encoded libraries and aptamers. We hope that this course will inspire future chemists to branch out on this topical field of designing new biomolecules for potent applications, including new therapeutic strategies.

Contents:

Chemistry of nucleosides and nucleotides. Post-functionalization methodologies, Combinatorial chemistry as selex for the production of DNA-encoded libraries and synthesis of aptamers.

Bases in organic chemistry and molecular biochemistry