Selective methods for medicinal chemistry

The quest for new therapeutic agents requires, for both industry and academic, methods that are sustainable and chemoselective. In this context, the course will present methods for C-C and C-X bond formation based on one or two electron processes. A particular emphasis will be put on the illustration of this methods on large scale synthesis in the context of medicinal chemistry .  Transition-metal catalyzed and radical processes will be independently discussed before merging to radical-polar cross-over reactions eventually leading to photoredox chemistry.

Palladium vs Copper for C-N bond formation

Selectivity in free radical chain reaction.

Non-chain free radical processes. Radical-polar cross over. Photoredox chemistry  

Basics of organic and organometallic chemistry