Nuclear magnetic resonance

This lecture will introduce the main features of NMR pulse sequences. A simplified theoretical formalism will be developed to describe and understand the evolution of macroscopic nuclear magnetization during the NMR experiment. The fundamental concept of multi-dimensional NMR will be introduced. Heteronuclear NMR will be addressed: the sensitivity and the quality of the data that are available for a selection of heteronuclei in the field of organic chemistry will be discussed. Finally, nuclear spin relaxation will be introduced, and its application to the determination of molecular dynamics and self-diffusion processes will be described. Tutorials will allow for completing theoretical concepts with exercises focused on applications. A practical session will allow students for applying the acquired knowledge to the acquisition of data targeting dynamic and/or structural analysis. Basis of solid-State NMR will also be introduced. 

Content:

Pulsed NMR and Fourier Transform

• Magnetic Resonance Phenomenon 
• What Do We Detect in NMR Spectroscopy?
• The NMR Spectrometer
• Pulsed NMR

Multi-dimensional NMR

• Principle of Multi-Dimensional NMR
• Implementation of a 2D NMR Experiment
• Analytical Strategies in 2D NMR

Relaxation

• Principle of Nuclear Relaxation
• Cross Relaxation

Introduction to Solid-State NMR

Fundamentals of NMR: magnetic properties of the nucleus, Zeeman effect, chemical shift, scalar spin-spin coupling. Dynamic process in molecular samples