From bonding to catalysis

This course is an introduction to organometallic catalysis by transition metals in homogeneous phase and allows students to understand the basic concepts of this domain. Particular emphasis is placed on the comprehension of reaction mechanisms and metal-ligand interactions in order to determine the optimal reaction conditions. Coordination chemistry for organometallic catalysis

Basic of coordination chemistry : M-C, M-H bonds Ligands : phosphines, Carbenes NHC Pi Ligands : cyclopentadienyl, allyl, alkene, alkyne… Elementary steps in organometallic chemistry: oxidative addition, reductive elimination, migratory insertion, nucleophilic and electrophilic attack. Basic catalysis concept. C-C coupling, metathesis

Transition-metal catalysis
Mizoroki-Heck coupling: mechanism – regioselectivity – Halide and pseudo halides reactant – Ligandless conditions – Cyclization – Stereochemical aspect and asymmetric variant. - Cross coupling: Mechanism – Kumadu-Corriu – Neigishi – Stille – Suzuki-Miyaura – Hiyama – Sonogashira - Allylic Alkylation 

Mastery of basic knowledge and concept in inorganic and organic chemistry.