Heteroelements and Heteroaromatics in organic synthesis

At the end of this course the student should be able to use the organic chemistry associated with  heteroelements for functional group interconversion, bond formation,  as well the syntheses and reactivities of heteroaromatic compounds. 

• Heteroelement for C-C and C-Het bond formation
  Phosphorus: Arbusov, preparation of phosphonium salts, Wittig, Wittig-Horner, Mitsunobu, Corey-Fuchs ... Sulfur: thioacetals, sulfonium and sulfoxonium ylides, beta anion, preparation and reactivity of sulfones, sulfoxides ... Silicon: synthesis and reactivity of silyl enol ethers, Peterson olefination, trialkylsilyl diazomethane ...
• Heteroaromatic Chemistry

Heterocycles constitutes the vast majority of all known organic compounds, and are key components of pharmaceuticals, agrochemical, electro-active polymers, flavorings… They are also found in many biologically significant natural products. This part of the module aims to provide an introduction to aromatic heterocycles by examining the properties, the reactivity patterns, and some important synthetic methods of the main monocyclic heteroaromatic compounds, including:

   - Electron-rich aromatic heterocycles (pyrroles, furans, thiophenes, diazoles)

   - Electron-deficient aromatic nitrogen heterocycles (pyridines, diazines)

On completion of this course you will be able to devise synthetic pathways to the above heteroaromatics from simple precursors, and suggest reagents and conditions for achieving their region-selective substitution.

Mastery of basic knowledge and concepts in organic chemistry