Durée
77 heures
Faculté
Faculté de Santé
Langue des enseignements
Anglais
Présentation
University Diploma : The Complement System, Diseases and Therapeutics
Program reference (to be mentioned in all correspondence): DUC921
Academic coordinator: Prof. Sophie Chauvet
Teaching format: synchronous * and asynchronous onlinelearning**
Asynchronous distance learning requires participants to be autonomous and highly motivated to progress through the programme.
* Live interactive videoconference sessions
** Flexible self-paced learning through online course materials, without the need for simultaneous participation with instructors or fellow students.
Applications must be submitted through the C@nditOnLine platform.
Objectifs
The University Diploma (DU) "Complement System, Diseases and Therapeutics" aims to provide specialized, structured, and up-to-date training on the fundamental, diagnostic, and therapeutic aspects of the complement system in human diseases.
This program addresses the growing needs of clinicians, biologists, researchers and industry confronted with the rapid expansion of knowledge and therapeutics targeting
complement. The program enables healthcare and research professionals to master the theoretical bases, the exploratory tools, the pathophysiological mechanisms and the therapeutic strategies associated with this essential immune system.
The educational objectives of the University Diploma (DU) are structured around the following axes:
- Understand the organization, regulation and effector functions of the complement system in innate and adaptive immunity.
- Integrate complement-driven pathophysiological mechanisms across major disease families: renal, autoimmune, hematological, neurological, ophthalmological, infectious, oncological, obstetrical and rare diseases.
- Master the principles of complement biological exploration (functional tests, immunochemical analyses, complement genetics) and their interpretation in a clinical context.
- Apply this knowledge to guide and optimize diagnostic and therapeutic management, notably with complement-targeting treatments (anti-C5, proximal complement inhibitors…).
- Critically appraise the scientific literature and ongoing innovations in the complement field, with a view to continuous professional development and the ongoing enhancement of expertise.
- Foster a transdisciplinary integration of fundamental and clinical knowledge, aligned with the training and innovation goals of FHU COMET.
This diploma aims to serve as a leading educational program, equipping participants with comprehensive expertise that is directly transferable to clinical, diagnostic, and research activities related to the complement system.
Compétences visées
Upon successful completion of the program, participants will be able to:
- Master the theoretical bases of the complement system, necessary to understand its physiological functions and its role in pathophysiological mechanisms of human disease.
- Interpret a complement biological workup, know the available diagnostic tools and understand their indications, limits and interpretation.
- Grasp pathophysiological and diagnostic aspects associated with complement dysfunction across a broad spectrum of pathologies (renal, autoimmune, neurological, oncological, hematological, ophthalmological, obstetrical, etc.).
- Apply complement-targeting therapeutic strategies, integrating indications, mechanisms of action, adverse effects, and follow-up modalities according to the clinical context.
- Perform a critical analysis of the scientific literature by assessing data quality, methodological rigor, and the clinical or translational implications of studies focusing on the complement system, complement-mediated diseases, and complement-targeted therapies
Programme
Program reference : DUC921
Total workload : 77 hours including
64 hours of lectures, 10 hours of interactive workshops, 3 hours written examination.
Academic year: du 03/12/26 au 31/05/27
The programme consists of five teaching modules, delivered approximately once per month. Continuous assessment throughout the program allows participants to monitor and validate their progress.
Location: fully online.
Modules
- Module 1 — Fundamentals of Complement Biology
- Module 2 — Complement in Kidney Diseases
- Module 3 — Haematology, oncology and transplantation
- Module 4 — Neurology and ophthalmology
- Module 5 — Internal medicine, metabolic disorders, primary immunodeficiency and infectious diseases and pregnancy
- Module 6 : FHU COMET Webinar Series
Teaching and Learning Resources, and Academic Support
Program team
Program lead: Prof. Sophie Chauvet (PU-PH, nephrologist).
Program coordinator: Dr Carine El-Sissy (medical biologist, immunology).
Pedagogical committee:
· Lubka Roumenina (research director, cancer and complement)
· Marie-Agnès Dragon-Durey (biologist, autoimmunity and complement)
· Joan Bitan (physician, immunology and complement).
Additional faculty includes:
Christoph Binder, Anna Blom, Benjamin Kaffenberger, Marina Botto, Idris Boudhabhay, Romain Brousse, Doryen Bubeck, Simon Clark, Chantal Dumestre-Perard, Jean-Paul Duong Van Huyen, Anna Duval, Christine Gaboriaud, Anne Grunenwald, Delphine Gobert, Véronique Frémeaux-Bacchi, Laurent Mesnard, Tiffany Jo Petrisko, Marie Frimat, Anderson Gregers, Alexandre Hertig, Markus Hoffmann, Sonata Jodele, Claudia Kemper, Ben King, Christina Lamers, Juliette Leon, Corentin Le Magueresse, Moglie Le Quintrec, Markus Huber-Lang, Marco Mannes, Nicolas Merle, Marie-Sophie Meuleman, Dror Mevorach, Paul Morgan, Monica Olcina, Edward Patz, Régis Peffault de la Tour, Matthew Pickering, Ruben Pio Oses, Valeria Ramaglia, Daniel Ricklin, Jeremie Rosain, Sean Stowell, Barbara Seitz-Polski, Pilar Martinez Martinez, Marc De Baets Trent Woodruff, Wioleta M. Zelek.
Material and Technical Resources
To promote an interactive and collaborative learning approach, various digital tools (to be specified where available) will be provided to enable participants to:
· exchange files and data
· share resources and information
· communicate easily outside the classroom and scheduled teaching sessions
Instructions for accessing the Moodle platform are provided in the welcome handbook.
Once logged into the Moodle homepage, participants will find a range of tutorials available in the “AIDE” section, designed to support them in discovering and getting started with the platform.
Methods for Monitoring Training Delivery and Assessing Learning Outcomes
Completion of the training is documented through the instructional design plan, technical activity logs from distance learning sessions, completed assignments, and connection records from the video-conferencing platform or electronic attendance signatures.
At the end of the program, participants complete an online satisfaction questionnaire immediately after training. The responses are analyzed, and a summary report is submitted to the program’s academic committee.
Contrôle des connaissances
Assessment Methods for Knowledge and Skills
- 5 online MCQs (each lasting 30–40 min), graded out of 20, coefficient 1 (online).
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- Written dissertation, graded out of 20, coefficient 1.
Diploma Validation Requirements
- Achieve a minimum overall average of 10/20 across all assessments
Tutorat
Responsive pedagogical support is provided throughout the training program. To facilitate communication with your designated tutor (name + position to be specified), you may ask questions via the Moodle discussion forum, by email, or during video-conference sessions.
Aménagements particuliers
Université Paris Cité is committed to providing personalized welcome and support for individuals with disabilities throughout their training journey.
Admission
Public cible
- Students holding a Master 1 or enrolled in Master 2 in life sciences, immunology, biology, health or related disciplines.
- Research professionals (engineers, researchers, PhD students, post-docs) working in immunology, medical biology, rare diseases, inflammation or innovative therapeutics.
- Health professionals: physicians (all relevant specialties), residents, pharmacists, medical biologists or clinicians involved in the care of complement-dependent pathologies.
- Pharmaceutical and biotech industry professionals involved in the development or evaluation of complement-targeted therapies.
Conditions d'admission
Admission to the program is subject to academic approval. Applicants must submit the following documents via C@nditOnLine:
- A curriculum vitae (CV)
- A cover letter explaining their motivation for enrolling in the program
- Copies of diplomas or qualifications demonstrating eligibility for admission to the program
Pré-requis
- Completed Master 1 level (sciences, biology, health, medicine, pharmacy or related disciplines).
- Working proficiency in English, required for the understanding of course materials and scientific publications.
Participants are required to have access to a computer and a stable internet connection.
Les clefs de la réussite
Practical guidance sheets are available at: http://www.reussir-en-universite.fr/index.html.
Modalités de candidature
Program reference: DUC921
1.
- Create and activate your user account on the C@nditOnLine platform (accessible via Chrome or Mozilla browsers).
- Carefully complete your personal information and upload all required supporting documents in PDF format only, namely:
- A copy (front and back) of a valid national identity card or passport
- A state-recognized diploma certifying eligibility for the requested program
- Click on “Mes candidatures”, then “Nouvelle candidature”.
- Select the relevant academic department (UFR de Médecine), the type of program (Diplôme Universitaire ou Inter-Universitaire ou DAEU), and the title of the desired training (DUC921- DU le système du complément, maladies et thérapeutiques), Specify the funding method.
- Upload your CV and cover letter for each selected program.
Additional documents to be uploaded on C@nditOnLine
- If you are a student in a Bachelor/Master/PhD program, a medical intern, or a junior doctor enrolled at a university: proof of enrollment for the current academic year in a national or state diploma program (excluding DU/DIU programs)
- If you benefit from financial support: proof of funding approval
INCOMPLETE APPLICATIONS WILL NOT BE PROCESSED.
IMPORTANT: For job seekers, please include your registration number, your employment agency details, and select “Pôle emploi” as the funding option during the application process.
Apply for the program by logging into the C@nditOnLine platform.
Droits de scolarité
TRAINING FEES* according to your profile
- For students (Master’s students enrolled in their second year, PhD candidates), medical residents and university-affiliated fellows : €1,000 (self-funded; valid university enrolment certificate for the current year in a National Diploma or State Diploma — excluding DU/DIU — to be uploaded to C@nditOnLine).
- For early postdoctoral researchers (within two years of PhD completion), people with AHU or CCA or hospital FFI or paramedical status for the current year hospital, or candidates who obtained within the previous two years a national or state Diploma (excluding DU/DIU programs): €1,350 (self-funded; supporting document to be uploaded to C@nditOnLine).
- For established postdoctoral researchers (more the two years after PhD completion), researchers, industry professionals and all others self-funded or fully or partially funded participants: € 2150
Administrative fee
An additional application fee* — €300 (waived for students already enrolled in a national diploma at Université Paris Cité for the same year).
*Training fees and application fees are subject to change by decision of the University’s governing bodies.
Et après ?
Poursuite d'études
Participants may continue to develop and expand their expertise by enrolling in additional university diploma programs, professional certification courses, or specialized seminars.
Contacts
Dernière mise à jour le 7 septembre 2026
