ECTS
120 crédits
Niveau d'études visé
BAC +5
Durée
2 ans
Faculté
Faculté des Sciences
Langue des enseignements
Anglais, Français
Présentation
The « In silico Drug Design-Design in silico of bioactive molecules, ISDD-Bioactive molecules» program is at the intersection of structural biochemistry, chemistry and in silico approaches. It responds to the needs of both the private and academic sectors to train professionals in the therapeutic innovation domain and for computational research of therapeutic molecules. This research domain is flourishing in Europe and in the world. This program is dedicated to bioactive molecule modeling and in silico pharmaceutical chemistry. It is built on specialties of different international universities and visiting professors and researchers. This program creates the possibility for earning a Franco-Italian double diploma: ISDD-Bioactive molecules and the Laurea Magistrale in Scienze Chimiche, from the Università degli Studi di Milano
Ce parcours forme les étudiants aux approches in silico, notamment à la chemoinformatique, à la bioinformatique structurale, à la modélisation des structures tri-dimensionnelles, à la modélisation computationnelle de leurs interactions avec les molécules médicaments, aux biostatistiques et à l’analyse de données, à la bioinformatique structurale et aux logiciels de docking et de criblage. Les trois premiers semestres se déroulent à l’université de Paris.
For further information : http://isddteach.sdv.univ-paris-diderot.fr
Objectifs
This program trains professionals from the private and public sectors, both in France and in Europe, who are involved in research through in silico approaches in the field of therapeutic innovation and/or oriented towards the development of pharmacological molecules.
The ISDD program provides training in all tasks related to the « Drug Discovery» process using in silico approaches, from theoretical to applications (for example, virtual screening of therapeutic targets, drug safety…)
It offers to students training in chemical biology based on the fundamental principles of chemistry, biochemistry, biophysics, pharmacology, molecular medicine, information technology, bioinformatics and biostatistics.
Compétences visées
With this program, the students will acquire sufficient skills to process computational-aided drug design in drug discovery and/or drug safety. More precisely, the students will gain competence in programming, algorithmic, biostatistics, math, molecular modelling, cheminformatics, structural bioinformatics, data analysis, virtual screening, docking and molecular dynamic. There are many ‘’work-together’’ projects, training the students to work as a team in a multidisciplinary domain. They have the possibility to perform an internship abroad, providing an opportunity to them to integrate international research project and to develop their ability to adapt to different project management and cultures.
Programme
The « In silico Drug Design-Design in silico of bioactive molecules, ISDD-Bioactive molecules» program, include a first semester in chemoinformatic at the university of Strasbourg, a second semester related to molecules bioactives at the university of degli studi di Milano. The semester 3 is on drug design and virtual screening at the university of Paris Diderot and the fourth semester is an internship on a research project in France or in a foreign country.
Many “team building” projects are proposed in the third semester.
At the end of the training, students are able to develop and apply diverse computational approaches for the identification of new hits molecules.
Numerous joint projects teach them to work in teams and to carry out their work in this multidisciplinary field.
The strong international orientation of this Master's degree allows students to develop their ability to adapt to different research systems and to integrate into international research projects.The multidisciplinary of the program is supported by universities of excellence at Paris Diderot, Strasbourg and Degli studi di Milano, and the involvement of national and international experts.
This program is made up of the following UEs:
Semester 1 (University of Strasbourg)
- Methodology (10 ECTS)
- Molecular Modeling (8 ECTS)
- Chemoinformatics (10 ECTS)
- Communication (2 ECTS)
Semester 2 (University Degli studi di Milano - Italy)
- Programming in C (6 ECTS)
- Structural Biology and enzymology (6 ECTS)
- Medicinal chemistry (6 ECTS)
- Simulation, Modelling and Biomolecules (6 ECTS)
- Bioactive molecules or equivalent module (6 ECTS)
Semester 3 (University of Paris)
- Data analysis in drug design (8 ECTS)
- Molecular analysis and dynamics & drug design (7 ECTS)
- High throughput screening : structure & ligand-based (5 ECTS)
- Molecular Space Analysis (4 ECTS)
- Preparation for Research in Drug Design (6 ECTS)
Semester 4
- Internship (30 ECTS)
Sélectionnez un programme
Master 1 Bioinformatique - Parcours : In silico drug design : bioactives molecules international
Semestre 1 à l'Université de Strasbourg
Méthodologie
10 créditsModélisation Moléculaire
8 créditsChémoinformatique
10 créditsCommunication
2 crédits
Semestre 2 à l'Université Degli Studi di Milano
Programmation C
6 créditsBiologie Structurale et Enzymologie
6 créditsChimie Medicinale
6 créditsSimulation, Modelisation et Biomolecules
6 créditsAu choix : 1 parmi 2
Master 2 Bioinformatique - Parcours : In silico drug design : bioactives molecules international
Bases de Unix et R (Mise à niveau)
0 créditsMise à niveau Toxicologie-Méthodologie
0 créditsAnalyse de données en drug design
8 créditsAu choix : 1 parmi 2
Projet python 1
3 créditsProgrammation python 2
3 crédits
Analyses de données en Drug Design
3 créditsApplication en Drug Design & QSAR
1 créditsSéminaires et R&D
1 crédits
Analyse, dynamique moléculaire en drug design
7 créditsModélisation structurale et dynamique
2 créditsExploration structurale des protéines
3 créditsAu choix : 1 parmi 2
Analyse dynamique des cibles I
2 créditsAnalyse dynamique des cibles II
2 crédits
Criblage haut-débit : structure & ligand-based
5 créditsStructure-based
3 créditsLigand-based
1 créditsHits to lead
1 crédits
Application de criblage haut-débit
2 créditsStage 1 (1 a 2 semaines)
1 créditsStage 2 (2 mois)
7 crédits
Stage 3
2 créditsProjets
3 créditsAu choix : 1 parmi 2
Bilan et perspective stage recherche+ projet dd
6 créditsStage 4 pro (mai-août)
19 crédits
Stages et projets tutorés
The last semester is an introductory research internship in academic and industrial laboratories in France or abroad.
Contrôle des connaissances
The first year of the master must be validated before proceeding to the second year of the master. All the UEs of each year must be validated with a grade of at least 10/20 to obtain the ISDD Master's degree.
The modality of knowledge control is based essentially on a terminal examination for each EU but also on a set of continuous control, oral examination, project evaluation. The student has the opportunity to re-sit tests of non-acquired UEs in a second examination session..
Tutorat
Tutored projects are proposed in the EUs within semester 3.
Admission
Public cible
This program is for students preferably with a background in chemistry or pharmacy or biologist with a strong interest in chemistry and informatic.
Conditions d'admission
This master's degree program welcomes students from various initial training programs with a bachelor's degree (universities or engineering schools).
Pré-requis
A degree in chemistry, pharmacy, biomedical sciences (with an interest in computer science) or computer science (with knowledge of chemistry or biology) is a prerequisite. Since M1 and M2 are taught in English, a B2 level is required at the entrance of M2.
Modalités de candidature
Recruitment is made on the basis of a file followed by an interview with the admissions committee in order to evaluate the adequacy of the student's training and to advise him/her on refresher courses and internship opportunities.
Et après ?
100%
Taux de réussite (The outlets are for research and professional purposes, the orientation is made at the level of the choice of research internships in academic laboratories or private companies. 98% of the students are recruited within 2 years after their Master's degree, more than 60% within 2 months after the Master's defense.)
Poursuite d'études
There are many opportunities to pursue a PhD in France or abroad, but also opportunities for direct integration into a professional environment .
Débouchés professionnels
There are many opportunities to pursue a PhD in France or abroad, but also opportunities for direct integration into a professional environment (pharmaceutical industry or EPST) after the Master's degree (or during the work-study program). It offers opportunities in pharmaceutical industries and "start-ups", national or international, private or academic research laboratories, or allows them to continue their studies by completing a French or international PhD. Students obtain positions as engineer, research assistant or manager directly after the M2 or as project manager, researcher, platform manager, after a thesis..
Researcher and project manager in structural bioinformatics, chemoinformatics, biostatistics, molecular modeling, in silico drug design, in chemical and pharmaceutical industries, in public or private drug design research and development laboratories, in pharmaceutical sectors, EPST such as CNRS, INSERM, INRA, CEA, hospitals.
Platform engineer in chemoinformatics, screening, structural bioinformatics, data analysis for the public service specialized
International
Mobilité internationale
Mobilité en première année au semestre 2, à l’université de Strasbourg puis à l’université DEgli studi di Milano, Italie, + possibilité de stage de recherche à l’international en M2
Contacts
Dernière mise à jour le 16 juin 2022
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