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Master Ingénierie de la santé - Parcours : Molecular and Cellular biotherapy (MCB)

Domaine : Sciences, Technologies, Santé
Mention : Ingénierie de la santé
  • ECTS

    120 crédits

  • Niveau d'études visé

    BAC +5

  • Durée

    2 ans

  • Langue des enseignements



The BME-Paris Master is designed to provide a 2-year education program in the field of bioengineering, at the cross-road of biomedical and engineering sciences. It results from a partnership between Université Paris Descartes, Arts-et-Métiers ParisTech and Université PSL.

Based on this unique partnership, this Master is founded on an educational policy that favors interdisciplinarity and students’ initiative as well as international perspective. This policy is supported by the top-level and complementary expertise and know-how of the three partners: engineering sciences in the three engineering schools within PSL (ESPCI Paris, Mines ParisTech and Chimie ParisTech) and Arts-et-Métiers ParisTech, on the one hand, and biomedical and health sciences at Université Paris Descartes, on the other. 
Teaching faculty is mostly from the partner institutions. Guest lecturers include hospital clinicians (AP-HP), and researchers from other schools and universities as well as from private companies (e.g. GE Healthcare, Philips Healthcare, Renault, Sanofi, Thalès, Materialise Medical, …).

Learning outcomes

The BME-Paris Master proposes a program of excellence intended for students with a wide variety of backgrounds (biology, chemistry, physics, mathematics, engineering as well as medicine, pharmacy and other health sciences…).

The overarching goals of the Master are:

  • to provide students with the knowledge and tools required in a wide range of the biomedical engineering fields;
  • to foster a fruitful collaborative spirit between engineering and medical students, that will eventually bridge the existing « culture gap » between the corresponding professions. 


While the second year (M2) offers five specialization tracks, the first year (M1) is devoted to strengthening and broadening students’ skills in specific engineering and biomedical subjects. Students are advised in their individual choices of teaching units, to bring them up to date on the fundamental science subjects they may not have acquired through their previous studies (eg physiology and anatomy for engineering students, or signal processing and mechanics for biology or medical students).

Molecular and Cellular Biotherpies (MCB) is one of the 5 M2 proposed tracks.


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The MCB track concerns two major categories of biotherapeutics applications: cell and gene therapy, and biopharmaceuticals. Cell and gene therapy differs from drug therapy in that it concerns the use of 'custom or "à la carte" therapeutic agents created for an individual patients, a domain in which few manufacturers operate. Biopharmaceuticals are complex macromolecules created by biotechnology, and involve genetic manipulation of living organisms, which differ from conventional chemically synthesized small molecules.
The specific pharmacological and immunological features of biotherapy products, considered to constitute a new generation of drugs, are studied in conjunction with the characteristics of target populations, clinical follow-up, and biological monitoring. The aim of this track is to train students of advanced scientific level in the field of biotherapy in order to prepare for careers in academia. These students may also find opportunities in industry at the national, European, and international level, particularly in biotechnology and medical research laboratories in teaching hospitals), as well as in cell and gene therapy firms.


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Compétences visées

- Respect scientific ethics

- Design and develop scientific projects

- Implement a project, define the objectives and context, carry out and evaluate the action

- Conduct and develop scientific and technical projects

- Analyze, diagnose and interpret the results of scientific experiments

- Know how to assess professional risks, implement specific evaluation methods

- Master specific methods and tools


Cross-curricular skills

- Work independently, manage time, self-evaluate.

- Use information and communication technologies.

- Conduct information research, identify access modes, analyze relevance, explain and transmit.

- Write clearly, prepare appropriate communication materials.

- Scientific communication in English.

- Working as a team: integrating, positioning, collaborating.

- Integrate into a professional environment: identify your skills and communicate them.

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La formation se déroule en anglais, à temps plein.

Deux stages de 2 mois obligatoires en Master 1 et un stage de 5 mois obligatoire en Master 2 dans un laboratoire de recherche académique, hospitalier ou industriel.

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Sélectionnez un programme

Master 1 Ingénierie de la santé

  • Open Your Mind seminars

    0 crédits
  • Scientific thinking and communication

    6 crédits
    • Languages (English or French)

      0 crédits
    • Medicine and Science

      4 crédits
    • Scientific communication

      2 crédits
  • 6 UE au choix

    24 crédits
    • Au choix : 6 parmi 15

      • Molecular & cellular biology for engineers

        4 crédits
      • From molecular to cellular and tisssue biology

        4 crédits
      • Anatomy & physiology for engineers

        4 crédits
      • Mathematics I : A mathematical introduction to data analysis

        4 crédits
      • Mathematics II : Applied Mathematics for biological systems

        4 crédits
      • Computer programming

        4 crédits
      • BioMedical modeling

        4 crédits
      • Biological modeling and dynamical systems

        4 crédits
      • Physics for bioImaging I

        4 crédits
      • Physics for bioImaging II

        4 crédits
      • Mechanics I : Basics in deformable solid mechanics

        4 crédits
      • Mechanics II : Continuous media mechanics

        4 crédits
      • Chemistry for engineers

        4 crédits
      • Supramolecular chemistry

        4 crédits
      • Chemical engineering of nanoparticles for therapy and diagnostic

        4 crédits
  • Scientific writing

    3 crédits
  • Ethics and Patents

    3 crédits
  • BioTech FabLab projects

    12 crédits
  • Internship

    12 crédits

Master 2 Ingénierie de la santé - Parcours : MCB

  • Open Your Mind seminars

    0 crédits
  • Interdisciplinary week

    3 crédits
  • Transversal skills development

    3 crédits
    • ESGT Meeting

      1 crédits
    • Scientific communication

      0 crédits
    • Statistics, Methodology & Literature Review

      2 crédits
  • Gene transfert strategies

    3 crédits
  • Basic immunology in biotherapies

    3 crédits
  • Stem cells and disease modelling

    3 crédits
  • Gene and cell therapy: Clinical applications - Part 1

    3 crédits
  • Gene and cell therapy: Clinical applications - Part 2

    3 crédits
  • Cancer therapies

    3 crédits
  • Tissue Engineering: Clinical Applications

    3 crédits
  • Osteoarticular repair

    3 crédits
  • Internship

    27 crédits
  • Ethical and Industrial Aspects

    3 crédits
    • Industrial Aspects of Biomedical Engineering

      2 crédits
    • Ethical Aspects of Biomedical Engineering

      1 crédits

Stages et projets tutorés

Contrôle des connaissances

Les modalités de contrôle des connaissances (MCC) reposent sur des schémas classiques d’évaluation pour les UEs : examen terminal écrit ou oral, contrôle continu ou mixte. Certaines UEs incluent à la fois des examens oraux et écrits.

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Aménagements particuliers

Pour les étudiants en situation de handicap vous pouvez prendre contact  avec le service accompagnement santé  handicap –

mél accueil.ash @ parisdescartes.fr - tél 01 76 53 17 72


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Public cible

Etudiants français et étrangers titulaires d’une licence ou d’un Master scientifique, étudiants en médecine ou en pharmacie, élève ingénieurs.

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Conditions d'admission

Conditions to apply for the 1st year of our master’s program (M1)

  • having obtained or being in the process of validating a Licence 3 or a Bachelor’s degree in science (particularly, but not restricted to, life and health sciences, engineering, chemistry, physics, mechanics, mathematics, computer science).
  • being a physiotherapist or a 4th year student in a physiotherapist school

Conditions to apply directly for the 2nd year of our master’s program (M2)

  • For students in science or engineering:
    • having obtained or being in the process of validating a Master 1
    • having obtained or being in the process of validating a Master’s degree 
    • being a 3rd year student in an engineering school or
    • being a 2nd year student in an engineering school (particularly Arts et Métiers ParisTech, Mines Paris Tech, Chimie ParisTech and ESPCI Paris) affiliated with the Master BME  Paris program for a double diploma
    • being a 2nd year student at ENS Paris


  • For students in health science (medical, pharmacy or dental schools):
    • being a 3rd year student in the Medicine-Science or Pharmacy-Science program at University Paris Descartes or at l’Ecole de l’Inserm Liliane Bettencourt
    • being an intern or Doctor of Medicine (MD), Pharmacy (Pharm.D), Dental Surgery (DDS) or Dental Medicine (DMD)
  • For physiotherapists or 4th year students in physiotherapist schools: you can apply directly for the M2 only if you are able to prove that you attended an additional research oriented curriculum (formation complémentaire à et pour la recherche)
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C1 level in English (TOEIC, TOEFL, …).

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Modalités de candidature

Online application and interview for preselected candidates.

Link to apply: http://bme.biomedicale.parisdescartes.fr/apply/

In preparing your application, please include the followings:

All higher education grade transcripts and diplomas (with French or English translations, if originals are in another language), two recommendation letters (in French or in English), resume and motivation letter (both in English), and proof of at least a C1 level in English (TOEIC, TOEFL, …).


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Liens utiles

Et après ?

Poursuite d'études


  • PhD in a field related to the M2 track followed by the student, in academia or jointly with a company (CIFRE PhDs).
  • R&D positions in large companies or startups, in almost all activity biomedical and biotech sectors.
  • Continuing medical or pharmacy school, or accessing it (« passerelle »), in either 2nd or 3rd year.

Business programs in biotech management (ESCP, EM Lyon / Centrale Supelec…)

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Passerelle vers médecine, pharmacie ou odontologie

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Mobilité internationale

Mobilité entrante importante. La part des étudiants internationaux représente 59,4% des effectifs en M1 et 29,2% de ceux de M2 (statistiques sur 2012-2017).

Mobilité sortante pour le stage de M1 ou de M2.

Convention avec l’université d’Hangzhou Dianzi (Chine) : formation délocalisée au niveau M1.

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  • Salima Hacein-Bey

    Responsable du diplôme
    • salima.hacein-bey @ aphp.fr
  • Franck Griscelli

    Responsable du diplôme
    • franck.griscelli @ gustaveroussy.fr
  • Barbara Dallez

    Contact administratif
    • +33 (0)1 76 53 46 90
    • barbara.dallez @ parisdescartes.fr
  • Isabelle Guenerie

    Contact administratif
    • +33 (0)1 76 53 46 64
    • isabelle.guenerie @ parisdescartes.fr

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